Note: Edo is the former name of Tokyo. The following is from http://en.wikipedia.org/wiki/History_of_Japan During the Edo Period (1603-1868), also called the Tokugawa period, the administration of the country was shared by over two hundred daimyō, the government of the federation was the Tokugawa Shogunate. The Tokugawa clan, leader of the victorious eastern army in the Battle of Sekigahara, was the most powerful of them, and for fifteen generations monopolized the title of Sei-i Taishōgun (often shortened to shōgun). With their headquarters at Edo (present-day Tōkyō), the Tokugawa commanded the allegiance of the other daimyō, who in turn ruled their domains with a rather high degree of autonomy.
pox powder,
Note: slang for mercury which was used to treat syphilis
the mercury cure,
Note: for syphilis?
“Niccolò Machiavelli could teach the shogun very little, I fancy.” “Indeed not, sir. The Florentine would be the novice, I credit.”
Note: Niccolò Machiavelli's most famous work, The Prince: http://kindle.amazon.com/work/the-prince-ebook/B002XNVKFG/B00266OVWE